Hormonal therapy may be appropriate in the following scenarios:

• fertility preservation in young patients under the guidance and ongoing management of a gynaecological oncology multidisciplinary team
• intrauterine and/or high-dose oral progestins in well-differentiated early-stage disease for patients who are unfit for surgery
• recurrent/metastatic disease – patients with progesterone-receptor-positive endometrial cancer recurrence may benefit from high-dose oral progesterone or other hormonal agents (NCI 2019).