Recurrent disease may be discovered by the patient or by surveillance in the post-treatment period. Symptoms can often present as:

• a lump or mass in any organ
• lymphadenopathy, particularly lymphadenopathy that lasts more than two weeks
• splenomegaly with or without systemic symptoms in the absence of, or after resolution of, any infection
• one or more of these systemic symptoms even in the absence of lymphadenopathy: fever, drenching night sweats, unexplained weight loss, frequent infections, unexplained