Recurrent or progressive disease is very common for patients with high-grade glioma. For some patients the initial treatment will not control the tumour(s). Others may present with symptoms of recurrent disease after a previous cancer diagnosis. Access to the best available therapies, including clinical trials, as well as treatment overseen by a multidisciplinary team, are crucial to achieving the best outcomes for anyone with recurrent or progressive disease.

Signs and symptoms will depend on the type of cancer initially diagnosed and the location of the recurrent or progressive disease. They may be discovered by the patient or by surveillance in the post-treatment period. Symptoms can often present as described in section 2.1.