With the low rates of curable CUP and the majority of patients palliated, it is likely that their current symptoms will worsen progressively, and this should be managed following discussions with palliative care specialists.

The supportive care needs, palliative care referral, increased support within the community and GP involvement of these patients are particularly important and should be reassessed.

Communication

The lead clinician should explain to the patient/carer the treatment intent, likely outcomes and side effects.