Treatment of APL differs in several important aspects from therapy of all other AML types. The presentation of APL is a medical emergency because of the high risk of death as a result of the associated coagulopathy. Rapid initiation of APL-specific therapy is essential and, in some cases, may precede formal confirmation of the diagnosis. Treating units must have protocols for intensive supportive care including guidelines for blood product administration in managing coagulopathy.

Patients should undergo molecular monitoring after treatment to guide further therapy.