The following signs and symptoms for NETs are not specific, but where persistent or suspicious further investigation could be warranted:

• abdominal pain
• bloating
• repeated dry flushing on the face and neck
• diarrhoea, even while not eating
• wheezing/bronchoconstriction (asthma-like symptoms)
• episodes of hypotension or palpitations
• unexplained right-sided heart disease
• unexplained weight loss
• fatigue.

For gastrointestinal NETs, more specific symptoms for the NET location are:

• watery diarrhoea
• cramping
• intermittent abdominal pain
• flushing
• asthma-like wheezing
• bowel obstruction
• flushing, diarrhoea and dyspnoea – classic triad symptoms are seen in less than 20 per cent of cases.

For pancreatic NETs, more specific symptoms for the NET location are:

• epigastric or back pain
• peptic ulcer disease
• diarrhoea
• intermittent hypoglycemic episodes (low blood sugar)
• diabetes
• rash.

For lung NETs, more specific symptoms for the NET location are:

• wheezing
• cough
• dyspnoea
• haemoptysis
• recurrent chest infections/pneumonia.

For paragangliomas and phaeochromocytomas, more specific symptoms for the NET location are:

• hypertension, often paroxysmal
• headache
• heavy sweating for no known reason
• a strong, fast or irregular heartbeat
• tremor
• pallor.

The presence of multiple signs and symptoms indicates an increased risk of NETs.