Metastatic disease will be detected most commonly by patients presenting with symptoms and less commonly via routine follow-up. Access to the best available therapies, including clinical trials, as well as treatment overseen by a multidisciplinary team, are crucial to achieving the best outcomes for anyone with metastatic disease.

Signs and symptoms will depend on the type of melanoma initially diagnosed and the location of metastatic disease. They may be discovered by the patient or by surveillance in the post-treatment period. Symptoms can often present as:

• any new or changing skin lesions
• a cutaneous lump
• palpable regional lymph nodes
• a persistent, unexplained, new symptom