STEP 3: Diagnosis, staging and treatment planning
Step 3 outlines the process for confirming the diagnosis and stage of melanoma and for planning subsequent treatment. The guiding principle is that interaction between appropriate multidisciplinary team members should determine the treatment plan.
All patients should have a complete skin check.
Unlike other cancers, most tests to confirm a melanoma diagnosis occur in the primary care setting before specialist referral.
Specialist management may include:
- complete excision (in rare instances where a punch, shave or incisional biopsy was performed pre-referral) or re-excision with recommended margins
- imaging (in some circumstances).
Reporting of biopsy results should be in the format as described by the Cancer Council Australia Melanoma Guidelines Working Party.
In some cases certain pathological subtypes of cancer or tumour tests (immunohistochemistry or tumour genetic tests) may suggest an underlying inherited cancer predisposition.
Anyone diagnosed with cancer should have a detailed personal and family cancer history taken. Consult relevant guidelines to determine if referral to a familial cancer service is appropriate.
A familial cancer service assessment can determine if genetic testing is appropriate. Genetic testing is likely to be offered when there is at least a 10 per cent chance of finding a causative ‘gene error’ (pathogenic gene variant; previously called a mutation). Usually testing begins with a variant search in a person who has had cancer (a diagnostic genetic test). If a pathogenic gene variant is identified, variant-specific testing is available to relatives to see if they have or have not inherited the familial gene variant (predictive genetic testing).
Medicare funds some genetic tests via a Medicare Benefits Schedule (MBS) item number but most are not. Depending on the personal and family history, the relevant state health system may fund public sector genetic testing.
Pre-test counselling and informed consent is required before any genetic testing. In some states the treating team can offer ‘mainstream’ diagnostic genetic testing, after which referral is made to a familial cancer service if a pathogenic gene variant is identified. The familial cancer service can provide risk management advice, facilitate family risk notification and arrange predictive genetic testing for the family. The familial cancer service will be relevant to each state and jurisdiction.
Relevant to melanoma, a small percentage (1–2 per cent) of melanomas are due to heritable variations in the CDKN2A and CDK4 genes. Patients that may be appropriate for referral are those with:
- more than one first-degree relative with melanoma (these patients should be referred to a dermatologist for clinical risk assessment)
- three or more relatives with melanoma and/or pancreatic cancer (these patients should be referred to a familial cancer service and undergo a genetic risk assessment) (RACGP 2019).
Visit the Centre for Genetics Education website for basic information about cancer in a family.
For detailed information and referral guidelines for melanoma risk assessment and consideration of genetic testing, refer to the Royal Australian College of General Practitioners 2019 publication, Genomics in general practice.
Staging is a critical element in treatment planning following surgical excision and should be clearly documented in the patient’s medical record.
Initial melanoma staging occurs with the complete excision of the primary lesion. Most melanomas (thickness < 0.8 mm with adequate margins) do not require further investigation.
Sentinel lymph node biopsy should be considered for patients with melanoma greater than 1 mm thickness and for patients with melanoma greater than 0.75 mm and other high-risk features such as ulceration, to provide optimal staging and prognostic information. If metastatic melanoma is detected, management of the regional lymph nodes region should be discussed. The options are observation with clinical and ultrasound review or completion lymph node dissection (CLND). CLND does not offer any survival benefit over close observation. A subset of patients who have metastatic melanoma detected in the sentinel nodes are likely to be referred to a medical oncologist to discuss the role of adjuvant systemic therapy. Sentinel node biopsy should be performed by a surgeon experienced in the procedure.
Node negative melanoma does not require imaging staging investigations.
If a patient has a positive sentinel lymph node biopsy or has had a primary melanoma and has palpable regional lymph nodes, further staging imaging and referral to a surgeon is required. Images are likely to be a CT scan or a PET-CT scan.
Evidence to suggest metastatic disease, where there has been a previous primary melanoma, or at the time of the diagnosis of a primary melanoma, specialist referral for further investigation may be required.
Visit the Cancer Institute New South Wales website for information about understanding the stages of cancer.
Staging investigations should be completed within two weeks of the specialist’s assessment.
Patient performance status is a central factor in melanoma care and should be clearly documented in the patient’s medical record.
Performance status should be measured and recorded using an established scale such as the Karnofsky scale or the Eastern Cooperative Oncology Group (ECOG) scale.
Patients with advanced stage primary melanoma, lymph node involvement or melanoma in unusual sites (e.g. mucosal and disseminated melanoma) are best managed by multidisciplinary teams in a specialist or melanoma facility (Cancer Council Australia Melanoma Guidelines Working Party 2019).
A number of factors should be considered at this stage:
- the patient’s overall condition, life expectancy, personal preferences and decision- making capacity
- discussing the multidisciplinary team approach to care with the patient
- appropriate and timely referral to an MDM
- pregnancy and fertility
- support with travel and accommodation
- teleconferencing or videoconferencing as required
The multidisciplinary team should meet to discuss patients with unusual pathology, any patient where treatment may be unclear, and all patients with stage III and IV disease, within four weeks of the initial diagnosis. The level of discussion may vary, depending on the patient’s clinical and supportive care factors. Some patients with non-complex melanoma may not be discussed by a multidisciplinary team; instead the team may have treatment plan protocols that will be applied if the patient’s case (melanoma) meets the criteria. If patients are not discussed at an MDM, they should at least be named on the agenda for noting. The proposed treatment must be recorded in the patient’s medical record and should be recorded in an MDM database where one exists.
Teams may agree on standard treatment protocols for non-complex care, facilitating patient review (by exception) and associated data capture.
Results of all relevant tests and access to images should be available for the MDM. Information about the patient’s concerns, preferences and social and cultural circumstances should also be available.
The multidisciplinary team requires administrative support in developing the agenda for the meeting, for collating patient information and to ensure appropriate expertise around the table to create an effective treatment plan for the patient. The MDM has a chair and multiple lead clinicians. Each patient case will be presented by a lead clinician (usually someone who has seen the patient before the MDM). In public hospital settings, the registrar or clinical fellow may take this role. A member of the team records the outcomes of the discussion and treatment plan in the patient history and ensures these details are communicated to the patient’s general practitioner. The team should consider the patient’s values, beliefs and cultural needs as appropriate to ensure the treatment plan is in line with these.
The multidisciplinary team should be composed of the core disciplines that are integral to providing good care. Team membership should reflect both clinical and supportive care aspects of care. Pathology and radiology expertise are essential.
See ‘About this OCP’ for a list of team members who may be included in the multidisciplinary team for melanoma.
Core members of the multidisciplinary team are expected to attend most MDMs either in person or remotely via virtual mechanisms. Additional expertise or specialist services may be required for some patients. An Aboriginal and Torres Strait Islander cultural expert should be considered for all patients who identify as Aboriginal or Torres Strait Islander.
The general practitioner who made the referral is responsible for the patient until care is passed to another practitioner who is directly involved in planning the patient’s care.
The general practitioner may play a number of roles in all stages of the melanoma pathway including diagnosis, referral, treatment, shared follow-up care, post-treatment surveillance, coordination and continuity of care, as well as managing existing health issues and providing information and support to the patient, their family and carer.
A nominated contact person from the multidisciplinary team may be assigned responsibility for coordinating care in this phase. Care coordinators are responsible for ensuring there is continuity throughout the care process and coordination of all necessary care for a particular phase (COSA 2015). The care coordinator may change over the course of the pathway.
The lead clinician is responsible for overseeing the activity of the team and for implementing treatment within the multidisciplinary setting.
Patients should be encouraged to participate in research or clinical trials where available and appropriate.
For more information visit the Cancer Australia website.
Cancer and cancer treatment may cause fertility problems. This will depend on the age of the patient, the type of cancer and the treatment received. Infertility can range from difficulty having a child to the inability to have a child. Infertility after treatment may be temporary, lasting months to years, or permanent (AYA Cancer Fertility Preservation Guidance Working Group 2014).
Patients need to be advised about and potentially referred for discussion about fertility preservation before starting treatment and need advice about contraception before, during and after treatment. Patients and their family should be aware of the ongoing costs involved in optimising fertility. Fertility management may apply in both men and women. Fertility preservation options are different for men and women and the need for ongoing contraception applies to both men and women.
The potential for impaired fertility should be discussed and reinforced at different time points as appropriate throughout the diagnosis, treatment, surveillance and survivorship phases of care. These ongoing discussions will enable the patient and, if applicable, the family to make informed decisions. All discussions should be documented in the patient’s medical record.
See the Cancer Council website for more information.
See validated screening tools mentioned in Principle 4 ‘Supportive care’.
A number of specific challenges and needs may arise for patients at this time; however, not all melanoma patients will need this level of support:
- assistance for dealing with psychological and emotional distress while adjusting to the diagnosis; treatment phobias; existential concerns; stress; difficulties making treatment decisions; anxiety or depression or both; psychosexual issues such as potential loss of fertility and premature menopause; history of sexual abuse; and interpersonal problems
- management of physical symptoms such as pain and fatigue (Australian Adult Cancer Pain Management Guideline Working Party 2019)
- malnutrition or undernutrition, identified using a validated nutrition screening tool such as the MST (note that many patients with a high BMI [obese patients] may also be malnourished [WHO 2018])
- support for families or carers who are distressed with the patient’s melanoma diagnosis
- support for families/relatives who may be distressed after learning of a genetically linked melanoma diagnosis
- specific spiritual needs that may benefit from the involvement of pastoral/spiritual care.
Additionally, palliative care may be required at this stage.
For more information on supportive care and needs that may arise for different population groups, see Appendices A and B, and special population groups.
In discussion with the patient, the lead clinician should undertake the following:
- establish if the patient has a regular or preferred general practitioner and if the patient does not have one, then encourage them to find one
- provide written information appropriate to the health literacy of the patient about the diagnosis and treatment and sun protection behaviours to the patient and carer and refer the patient to the Guide to best cancer care (consumer optimal care pathway) for melanoma, as well as to relevant websites and support groups as appropriate
- provide a treatment care plan including contact details for the treating team and information on when to call the hospital
- discuss a timeframe for diagnosis and treatment with the patient and carer
- discuss the benefits of multidisciplinary care and gain the patient’s consent before presenting their case at an MDM
- provide brief advice and refer to Quitline (13 7848) for behavioural intervention if the patient currently smokes (or has recently quit), and prescribe smoking cessation pharmacotherapy, if clinically appropriate
- recommend an ‘integrated approach’ throughout treatment regarding nutrition, exercise and minimal or no alcohol consumption among other considerations
- communicate the benefits of continued engagement with primary care during treatment for managing comorbid disease, health promotion, care coordination and holistic care
- where appropriate, review fertility needs with the patient and refer for specialist fertility management (including fertility preservation, contraception, management during pregnancy and of future pregnancies)
- be open to and encourage discussion about the diagnosis, prognosis (if the patient wishes to know) and survivorship and palliative care while clarifying the patient’s preferences and needs, personal and cultural beliefs and expectations, and their ability to comprehend the communication
- encourage the patient to participate in advance care planning including considering appointing one or more substitute decision-makers and completing an advance care directive to clearly document their treatment preferences. Each state and territory has different terminology and legislation surrounding advance care directives and substitute decision-makers.
The lead clinician has these communication responsibilities:
- involving the general practitioner from the point of diagnosis
- ensuring regular and timely (within two weeks of the decision about management) communication with the general practitioner about the diagnosis, treatment plan and recommendations from MDMs and inviting them to participate in MDMs (consider using virtual mechanisms)
- supporting the role of general practice both during and after treatment
- discussing shared or team care arrangements with general practitioners or regional melanoma specialists, or both, together with the patient.
Refer to Principle 6 ‘Communication’ for communication skills training programs and resources.