Antimicrobial prophylaxis and immunoglobulin supplementation (in hypogammaglobulinaemic patients who meet national prescribing criteria) is recommended. Specific antimicrobial prophylaxis should be prescribed based on established guidelines (national guidelines and eviQ) and the results of tests for occult or latent infection (see 3.1 Specialist diagnostic work-up). This includes, but

is not limited to, the particular risk of reactivation of latent hepatitis B associated with anti-CD20 monoclonal antibodies. Patients with hepatitis B core antibody require a documented plan for antiviral therapy and ongoing monitoring.

Yearly seasonal flu vaccination and five-yearly pneumococcal vaccination should be encouraged in accordance with the Australian National Immunisation Schedule, as should COVID vaccination boosters as/if the evolving evidence supports this approach.