Low-grade lymphomas frequently present with symptoms of gradual onset occurring over many weeks or several months. People can often be asymptomatic at diagnosis, with low-grade lymphomas discovered incidentally after imaging or laboratory tests reveal an abnormality.

The following signs and symptoms should be investigated:

• a lump or mass in any organ
• lymphadenopathy, particularly lymphadenopathy persistent beyond two weeks
• splenomegaly with or without systemic symptoms in the absence of, or after resolution of, any infection
• one or more of these systemic symptoms even in the absence of lymphadenopathy: fever, drenching night sweats, unexplained weight loss, frequent infections
• unexplained cytopenias
• persistent

The presence of multiple signs and symptoms, particularly in combination with other underlying risk factors, suggesting lymphoma should be considered more prominently in the differential diagnosis.