Risk-reducing surgery may be considered for women with:

• non-genetic conditions where there is an increased risk of endometrial cancer such as atypical hyperplasia
• genetic conditions (e.g. Lynch syndrome or PTEN mutation).

Women considering risk-reducing surgery should have a thorough family history taken, including male relatives, and consider referral to a familial cancer service to define the actual risk not only for the individual but also for other family members.