1.2 Risk factors
The risk factors for developing endometrial cancer include:
- age
- obesity
- diabetes
- endometrial hyperplasia
- Lynch syndrome (40–60 per cent lifetime risk of endometrial cancer)
- a family history of endometrial cancer in a first-degree relative
- PTEN gene mutations
- unopposed postmenopausal oestrogen therapy
- endometrial hyperplasia
- nulliparity
- anovulation
- early menarche and late menopause
- tamoxifen use in postmenopausal women
- hormone secreting tumour of the ovary (granulosa cell tumour) (Cancer Australia 2019b; NCI 2019).