TKI-related side effects can significantly affect quality of life and have the potential to be life-threatening.

Comprehensive side effect management is essential since lifelong treatment may be required, and treatment with TKIs can impact physical, psychological, nutritional and general wellbeing.

From the time of diagnosis, the treating team should offer patients appropriate psychosocial and supportive care and symptom-related interventions as part of routine care. The approach should be personalised to meet each patient’s needs, values and preferences.

Managing side effects may be complex and requires optimal communication between the treating clinician, patient, general practitioner and appropriate specialties in the multidisciplinary team.