General practitioners should be aware of the possibility of CML in patients with leucocytosis, or those with non-specific symptoms of fatigue, weight loss, sweats and malaise. Early satiety and abdominal discomfort may be related to progressive splenomegaly. Most cases of mild leucocytosis with neutrophilia will be due to other causes, but a PCR test for BCR-ABL1 to screen for CML should be ordered if the white cell count is over 25, leucocytosis or thrombocytosis is confirmed on a repeat blood test, or there are features on the blood film that raise the possibility of CML.